Detection of Polycyclic Aromatic Hydrocarbon-DNA Adducts in Human Lung
نویسندگان
چکیده
منابع مشابه
Detection of polycyclic aromatic hydrocarbon-DNA adducts in human lung.
Molecular dosimetry for polycyclic aromatic hydrocarbon-DNA adducts, genetic predisposition to cancer, and their interrelationships are under study in numerous laboratories. This report describes a modified 32P-postlabeling assay for the detection of polycyclic aromatic hydrocarbon-DNA adducts that uses immunoaffinity chromatography to enhance chemical specificity and quantitative reliability. ...
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The presence of serum antibodies to the diol-epoxide DNA adducts of representative polycyclic aromatic hydrocarbons (PAH), chrysene, benz[a]anthracene and benzo[a]pyrene, was determined by ELISA using serum samples obtained from normal healthy individuals. Antibodies that reacted against PAH adducted-DNA, but not against PAH-adducted protein, were found in the serum of approximately 40% of the ...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1993
ISSN: 0091-6765
DOI: 10.2307/3431495